Schilder's disease is a rare progressive demyelinating disorder (the myelin sheath of neurons are damaged) which usually begins in childhood. It is also referred to as diffuse myelinoclastic sclerosis.
The onset of the disease is typically in children between 5 and 14 years old, but cases in adults are also possible.
Symptoms may include:
Schilder's disease is a variant of multiple sclerosis. It is not the same as Addison-Schilder disease (adrenoleukodystrophy).
The criteria for diagnosis are:
As with multiple sclerosis, the course and prognosis of Schilder's disease are unpredictable. For some individuals the disorder is progressive with a steady, unremitting course. Others may experience significant improvement and even remission. In some cases, Schilder's disease is fatal.
Treatment for the disorder follows the established standards in multiple sclerosis and includes corticosteroids, beta-interferon or immunosuppressive therapy, and symptomatic treatment.