Saanichton, BC

Dr. Miguel A. Lipka

Chronic Inflammatory Demyelinating Polyneuropathy

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Chronic inflammatory demyelinating polyneuropathy (CIDP) is a neurological disorder characterized by progressive weakness and impaired sensory function in the legs and arms.

Although it can occur at any age and in both genders, CIDP is more common in young adults, and in men more so than women.

The disorder, which is sometimes called chronic relapsing polyneuropathy, is caused by damage to the myelin sheath (the fatty covering that wraps around and protects nerve fibers) of the peripheral nerves.

CIDP is closely related to Guillain-Barre syndrome and it is considered the chronic counterpart of that acute disease.

CIDP often presents with symptoms that include:

  • Tingling or numbness (beginning in the toes and fingers)
  • Weakness of the arms and legs
  • Loss of deep tendon reflexes (areflexia)
  • Fatigue
  • Abnormal sensations

The course of CIDP varies widely among individuals. Some may have a bout of CIDP followed by spontaneous recovery, while others may have many bouts with partial recovery in between relapses. The disease is a treatable cause of acquired neuropathy and initiation of early treatment to prevent loss of nerve axons is recommended. However, some individuals are left with some residual numbness or weakness.

Treatment for CIDP includes corticosteroids such as prednisone, which may be prescribed alone or in combination with immunosuppressant drugs. Plasmapheresis (plasma exchange) and intravenous immunoglobulin (IVIg) therapy are effective. IVIg may be used even as a first-line therapy. Physiotherapy may improve muscle strength, function and mobility, and minimize the shrinkage of muscles and tendons and distortions of the joints.